The Real School in Izyum was built in 1882. 

Real schools were, to some extent, analogous to modern technical colleges—their curriculum was geared toward training personnel for the needs of industry and commerce. Graduates of real schools were not eligible to enrol in university.

The building is an architectural landmark in the eclectic (historicist) style with some Gothic Revival elements. The architect of the school is unknown, but it is likely that it was K. Tolkunov, who built a real school in Kharkiv in a similar style in 1877.

School No. 4 is currently located in the building.

From 1937 to 1940, the Ukrainian writer Dmytro Shlapak attended the school, as evidenced by a commemorative plaque.

In 2017, a time capsule containing a message to the students of 2067 was embedded in the wall.

Current address: Staroposhtova Street, 22

The school was destroyed during World War II but was rebuilt in 1950–1951.

School No. 4 was destroyed once again as a result of Russian shelling in 2022.